Tuesday, June 21, 2011

ASC and Gene Therapy

A fascinating article from Science Daily:
"They used synthetic proteins called zinc finger nucleases (ZFNs) to target a corrective gene at a specifically defined location in the genome of the X-CGD iPS cells. The iPS cells were then carefully screened to identify those containing a single copy of the corrective gene properly inserted only at the safe site. The researchers observed that some of the gene-corrected iPS cells could differentiate into neutrophils that produced normal levels of hydrogen peroxide, effectively 'correcting' the disease."
Taking defective blood stem cells, and patching their programming!

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